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Otolaryngology, ENT & Sinus News Provided by Dallas ENTRole of fungi in pathogenesis of chronic rhinosinusitis: the hypothesis rejectedJanuary 31, 2012, 5:00 am by Current Opinion in Otolaryngology & Head and Neck SurgeryPurpose of review: Fungi have been suggested to play an important role in the pathogenesis of chronic rhinosinusitis (CRS). This review describes the recent knowledge concerning the role of fungi in the pathogenesis of CRS and allergic fungal rhinosinusitis (AFRS) and the clinical implications for treatment. Recent findings: Recent studies show that, although there are several potential deficits in the innate and potentially also in the acquired immunity of CRS patients that might reduce or change their ability to react to fungi, there are not many arguments to suggest a causative role for fungi in CRS with or without nasal polyps. However, due to the intrinsic or induced change in immunity of CRS patients, fungi might have a disease-modifying role. The fact that AFRS is more prevalent in warm and humid areas may point to fungi as a factor in this disease. Summary: Almost a decade after the launching of the hypothesis by Ponikau, the absence of convincing immunological data or evidence for clinical improvement of CRS upon therapy with antifungal agents now means that the hypothesis that fungi play a role in a majority of the cases of CRS has to be rejected and antifungal treatment should not be used.
More from Current Opinion in Otolaryngology & Head and Neck Surgery Editorial introductions Current Opinion in Otolaryngology & Head and Neck Surgery: May 31, 2012, 6:00 am No abstract available Practical clinical management strategies for the allergic patient with chronic rhinosinusitis Current Opinion in Otolaryngology & Head and Neck Surgery: May 31, 2012, 6:00 am Purpose of review: Allergic rhinitis often coexists with chronic rhinosinusitis (CRS). The purpose of this review is to provide a practical algorithm for the treatment of patients with allergic rhinitis and CRS. Recent Surgical options for the allergic rhinitis patient Current Opinion in Otolaryngology & Head and Neck Surgery: May 31, 2012, 6:00 am Purpose of review: Allergic rhinitis is a very common disorder that affects millions of patients annually and the hallmark complaint of nasal obstruction significantly impacts the quality of life. Many surgical options Beyond voice: perceptions of gender in male-to-female transsexuals Current Opinion in Otolaryngology & Head and Neck Surgery: May 31, 2012, 6:00 am Purpose of review: This review covers recent research findings that demonstrate the effectiveness of speech pathology intervention in enabling male-to-female transsexual individuals to portray their gender identity through speech. Research reports that Speech therapy and rehabilitation Current Opinion in Otolaryngology & Head and Neck Surgery: May 31, 2012, 6:00 am No abstract available
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